Sudafed, Singulair Equally Effective

Feb. 20, 2006 — A widely endorsed asthma and sensitivity sedate proved to be no more viable for treating roughage fever symptoms than a much cheaper over-the-counter decongestant in a newly detailed ponder.

Feed fever sufferers within the ponder who took the over-the-counter medicate Sudafed 24 Hour (pseudoephedrine) also experienced no more sleep issues or other side effects than people who took the medicine sedate Singulair.

That came as a enormous surprise to the researchers, who anticipated to see more anxiety and a sleeping disorder among the pseudoephedrine users.

« It may be that rest problems weren’t an issue because the people in the study took the once-a-day dose (240 milligrams) of pseudoephedrine within the morning, » study co-author Robert M. Naclerio, MD, tells WebMD. « [Feed fever] side effects also progressed, and this was likely to have a positive effect on rest. »

40 Million Sufferers

More than 40 million Americans suffer from regular hay fever, known medically as allergic rhinitis.

In the head-to-head comparison, Sudafed 24 Hour and Singulair proved equally compelling for treating the most common feed fever indications, such as sniffling, nasal clog, runny nose, and nose and throat itchiness.

The College of Chicago think about included 30 feed fever sufferers who took 10-milligram doses of montelukast (Singulair) each morning for two weeks and 28 who took the once-a-day, 240-milligram measurement of pseudoephedrine. The consider was financed by Singulair manufacturer Merck & Co. Inc. Merck is a WebMD sponsor.

Time-released 240-milligram capsules of pseudoephedrine fetched around 80 cents a day on line, compared with about $3 for 10 milligrams of Singulair.

« Our speculation was that montelukast would have additional benefits and pseudoephedrine would interfere with rest, but when we compared them head-to-head we found that for the treatment of unfavorably susceptible rhinitis, these drugs were essentially indistinguishable, » says researcher Fuad M. Baroody, MD.

The over-the-counter pseudoephedrine really demonstrated to be somewhat more viable for decreasing nasal blockage than Singulair, the researchers composed.

The study is published in the February issue of the Files of Otolaryngology – Head and Neck Surgery.

Not First-Line Drugs

But not one or the other of the drugs are the foremost widely recommended treatments for regular hypersensitivities, says asthma and hypersensitivity master Philip E. Gallagher, MD.

He notes that nasal steroid sprays, like Flonase, Nasacort, and Rhinocort, are considered the first-line prescription drugs for the treatment of feed fever. And the nonsedating antihistamine loratadine (Claritin) is considered the first-line, over-the-counter sensitivity treatment.

Gallagher could be a private hone allergist in Erie, Dad., and could be a spokesman for the American Academy of Sensitivity, Asthma, and Immunology.

He says the College of Chicago ponder appears that an over-the-counter sedate can work fair as well as a prescription medicine for many people with regular sensitivities.

« People who have gentle, intermittent side effects do not essentially have to be compelled to run to their specialists, » he says. « The over-the-counter drugs can be exceptionally effective. »

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